Brain derived neurotrophic factor (BDNF) levels in depressed women treated with open-label escitalopram.
作者： Mihai Bran , Maria Ladea
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摘要: SUMMARY Background: Recent studies suggest the important role of brain derived neurotrophic factor (BDNF) in etiopathogenesis major depressive disorder (MDD) and mechanism action antidepressants. This study aimed to correlate serum levels BDNF clinical symptoms patients with MDD before after 6 months treatment escitalopram. Subjects methods: Twenty women diagnosed 20 aged-matched healthy female controls were recruited. The received escitalopram 10-20 mg/day. measured at inclusion, week 4, 12 24. Montgomery-Asberg Depression Rating Scale (MADRS) was used assess severity evolution patients. Statistical analysis performed using both observed cases last observation carried forward. Results: At baseline, low associated MDD. In MDD, seems have a positive effect on parallel response. Conclusions: suggests that good under might be increases
参考文章(18)
Armando Piccinni, Donatella Marazziti, Mario Catena, Luciano Domenici, Alessandro Del Debbio, Carolina Bianchi, Claudio Mannari, Claudia Martini, Eleonora Da Pozzo, Elisa Schiavi, Alessandra Mariotti, Isabella Roncaglia, Agnese Palla, Giorgio Consoli, Luca Giovannini, Gabriele Massimetti, Liliana Dell'Osso, Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments Journal of Affective Disorders. ,vol. 105, pp. 279- 283 ,(2008) , 10.1016/J.JAD.2007.05.005
Eiji Shimizu, Kenji Hashimoto, Naoe Okamura, Kaori Koike, Naoya Komatsu, Chikara Kumakiri, Michiko Nakazato, Hiroyuki Watanabe, Naoyuki Shinoda, Sin-ichi Okada, Masaomi Iyo, Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants Biological Psychiatry. ,vol. 54, pp. 70- 75 ,(2003) , 10.1016/S0006-3223(03)00181-1
Masae Mitoma, Reiji Yoshimura, Atsuko Sugita, Wakako Umene, Hikaru Hori, Hideki Nakano, Nobuhisa Ueda, Jun Nakamura, Stress at work alters serum brain-derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress? Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 32, pp. 679- 685 ,(2008) , 10.1016/J.PNPBP.2007.11.011
Ronald S. Duman, Role of neurotrophic factors in the etiology and treatment of mood disorders Neuromolecular Medicine. ,vol. 5, pp. 11- 25 ,(2004) , 10.1385/NMM:5:1:011
Omer Aydemir, Artuner Deveci, Fatma Taneli, The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 29, pp. 261- 265 ,(2005) , 10.1016/J.PNPBP.2004.11.009
Masatake Kurita, Satoshi Nishino, Maiko Kato, Yukio Numata, Tadahiro Sato, Plasma Brain-Derived Neurotrophic Factor Levels Predict the Clinical Outcome of Depression Treatment in a Naturalistic Study PLoS ONE. ,vol. 7, pp. e39212- ,(2012) , 10.1371/JOURNAL.PONE.0039212
Marek Lommatzsch, Doerte Zingler, Katharina Schuhbaeck, Katharina Schloetcke, Christiana Zingler, Peter Schuff-Werner, Johann Christian Virchow, The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiology of Aging. ,vol. 26, pp. 115- 123 ,(2004) , 10.1016/J.NEUROBIOLAGING.2004.03.002
Srijan Sen, Ronald Duman, Gerard Sanacora, Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biological Psychiatry. ,vol. 64, pp. 527- 532 ,(2008) , 10.1016/J.BIOPSYCH.2008.05.005
Félicien Karege, Guido Bondolfi, Nicola Gervasoni, Michèle Schwald, Jean-Michel Aubry, Gilles Bertschy, Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biological Psychiatry. ,vol. 57, pp. 1068- 1072 ,(2005) , 10.1016/J.BIOPSYCH.2005.01.008
A. Saffet Gonul, F. Akdeniz, F. Taneli, O. Donat, Ç. Eker, S. Vahip, Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients European Archives of Psychiatry and Clinical Neuroscience. ,vol. 255, pp. 381- 386 ,(2005) , 10.1007/S00406-005-0578-6