Identification of Differentially Expressed MicroRNAs in Osteosarcoma.
作者： Rishi R. Lulla , Fabricio F. Costa , Jared M. Bischof , Pauline M. Chou , Maria de F. Bonaldo
DOI: 10.1155/2011/732690
关键词:
摘要: A limited number of reports have investigated the role microRNAs in osteosarcoma. In this study, we performed miRNA expression profiling osteosarcoma cell lines, tumor samples, and normal human osteoblasts. Twenty-two differentially expressed were identified using high throughput real-time PCR analysis, 4 (miR-135b, miR-150, miR-542-5p, miR-652) confirmed validated a different group tumors. Both miR-135b miR-150 been previously shown to be important cancer. We hypothesize that dysregulation may contribute tumorigenesis. They might also represent molecular biomarkers or targets for drug development
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