Influence of Amide versus Ester Linkages on the Properties of Eight-Armed PEG-PLA Star Block Copolymer Hydrogels
作者： Sytze J. Buwalda , Pieter J. Dijkstra , Lucia Calucci , Claudia Forte , Jan Feijen
DOI: 10.1021/BM901080D
关键词:
摘要: Water-soluble eight-armed poly(ethylene glycol)-poly(l-lactide) star block copolymers linked by an amide or ester group between the PEG core and PLA blocks (PEG-(NHCO)-(PLA)8 PEG-(OCO)-(PLA)8) were synthesized stannous octoate catalyzed ring-opening polymerization of l-lactide using amine- hydroxyl-terminated PEG. At concentrations above critical gel concentration, thermosensitive hydrogels obtained, showing a reversible single gel-to-sol transition. similar composition PEG-(NHCO)-(PLA)8 formed at significantly lower polymer had higher storage moduli. Whereas hydrolytic degradation/dissolution PEG-(OCO)-(PLA)8 takes place preferential hydrolysis bond block, degrade through bonds in main chain. Because their relatively good mechanical properties slow degradation vitro, are inte...
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