Single-Channel Microchip for Fast Screening and Detailed Identification of Nitroaromatic Explosives or Organophosphate Nerve Agents

摘要: A single-channel chip-based analytical microsystem that allows rapid flow injection measurements of the total content organic explosive or nerve agent compounds, as well detailed micellar chromatographic identification individual ones, is described. The protocol involves repetitive (screening) assaysto provide a timely warning and alarmand switching to separation (fingerprint identification) mode only when harmful compounds are detected. While electrokinetic chromatography, in presence sodium dodecyl sulfate (SDS), used for separating neutral nitroaromatic an operation without SDS leads high-speed “total” explosives content. Switching between “flow injection” “separation” modes accomplished by rapidly exchanging SDS-free SDS-containing buffers channel. Amperometric detection was monitoring separation. Key factors influenci...