An optimized lanthanide-chlorophyll nanocomposite for dual-modal imaging-guided surgery navigation and anti-cancer theranostics.

摘要: In this research, an optimized phosphor combined with naturally green chlorophyll (Phosphor-Chlorophyll, denoted as Ph-chl) was designed for dual-modal luminescence-guided anti-tumor surgery and photodynamic therapy (PDT). A genetic algorithm (GA) is used to solve the “low up-conversion luminescence (UCL) short-wavelength infrared (SWIR) intensity” problem by coding proportions of elements in order find optimal enhanced red UCL emission SWIR using Yb/Er core Yb/Nd shell. Moreover, when phosphors different light colors (blue green) are control, results indicate that energy donor have high PDT efficiency activate reactive oxygen species (ROS) production. Additionally, due penetration retention (EPR) effect, as-synthesized Ph-chl could be navigation a higher imaging effect focusing on cancer rather than normal tissues paracancerous tissue. Thus, guided properties final will promote its further use minimally-invasive endoscopic clinical navigation.