Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease.
作者： Emanuele Barbato , Jozef Bartunek , Fabio Mangiacapra , Sebastiano Sciarretta , Rosita Stanzione
DOI: 10.1016/J.JACC.2012.02.017
关键词:
摘要: Objectives The aim of this study was to investigate the impact rs5065 atrial natriuretic peptide (ANP) gene variant on coronary artery disease (CAD) and its outcomes gain potential mechanistic insights association with CAD. Background Either modified ANP plasma levels or structural alterations have been involved in development cardiovascular events. Methods Three hundred ninety-three control subjects 1,004 patients undergoing angiography for suspected CAD (432 stable angina [SA], 572 acute syndrome [ACS]) were genotyped variant. Data SA ACS groups replicated an independent population 482 (rSA) 675 patients, respectively. Clinical follow-up available both rSA patients. Plasma N-terminal-proANP, myeloperoxidase, lipoprotein-associated phospholipase A2, oxidized low-density lipoprotein assessed a subgroup Results minor allele (MA) predictor (odds ratio: 1.90; 95% confidence interval: 1.40 2.58, p Conclusions MA associates increased susceptibility has unfavorable prognostic value
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