Fosfomycin: Laboratory studies.

摘要: Fosfomycin, a nontoxic broad-spectrum antibiotic, different in structure from all previously described antibiotics, acts selectively by inhibiting cell wall formation. It was overlooked during many years of screening because antagonism culture medium ingredients and frequent occurrence resistant mutants. is effective man the neutralizing substances are not present mutants most species avirulent. Fosfomycin has favorable pharmacologic characteristics. cross resistant, does show antagonism, been used successfully combinations. An insoluble calcium salt oral formulation sodium for parenteral administration. Overall success rates 86% were reported with 1,000 patients Spain 79% Japan.