Metal centers in the anaerobic microbial metabolism of CO and CO2

摘要: Carbon dioxide and carbon monoxide are important components of the cycle. Major research efforts underway to develop better technologies utilize abundant greenhouse gas, CO2, for harnessing ‘green’ energy producing biofuels. One strategy is convert CO2 into CO, which has been valued many years as a synthetic feedstock major industrial processes. Living organisms masters CO chemistry and, here, we review elegant ways that metalloenzymes catalyze reactions involving these simple compounds. After describing chemical physical properties shift focus enzymes metal clusters in their active sites transformations two molecules. We cover how centers on dehydrogenase interconversion pyruvate oxidoreductase, contains thiamin pyrophosphate multiple Fe4S4 clusters, catalyzes addition elimination during intermediary metabolism. also describe nickel center at site acetyl-CoA synthase utilizes generate central metabolite, acetyl-CoA, part Wood-Ljungdahl pathway, channelled from site. corrinoid iron–sulfur protein interacts with synthase. This uses vitamin B12 cluster key methyltransferase reaction an organometallic methyl-Co3+ intermediate. Studies enzymology practical significance, offer fundamental insights biochemical metallocenters act nucleophiles form intermediates C–C C–S bond formations.