DIFFERENTIATION OF THE ANTITHYROID ACTION OF THIOURACIL, THIOUREA AND PABA FROM SULFONAMIDES BY IODIDE ADMINISTRATION

摘要: IN NOVEMBER, 1941, Mackenzie, Mackenzie and McCollum (1941) reported that sulfaguanidine produced a hyperplastic goitre in the rat. At same time Richter Clisby (1942) described similar changes thyroids of rats poisoned with phenylthiourea. Shortly thereafter March, Mackenzies demonstrated goiterogenic activity four additional sulfonamides, thiourea itself. It was thus clear phenylthiourea due to moiety rather than any groupings shared common sulfaguanidine; and, not one but two classes compounds had been discovered.