Macromolecular drug transport into the brain using targeted therapy

摘要: The brain forms a vascular barrier system comprised of the blood-brain (BBB) and blood-CSF barriers. Together they prevent passage number drugs from bloodstream into parenchyma, because their molecules are either hydrophilic, too large or both. In many disorders affecting CNS, these barriers physically intact, which limits entry with potentially important therapeutic implications. BBB is most relevant against drug delivery to as area about 1000 times larger than that barrier. Moreover, transport through choroid plexus directed ventricular system, only allowing transported access cells near subarachnoid surfaces. This review outlines possible routes for targeted macromolecules like polypeptides, siRNA cDNA. compartment, targeting should interact specifically proteins expressed exclusively by cells, therefore uptake elsewhere in body. Preferably, molecule be conjugated carrier allows defined cargo. However, evidence such targetable drug-carrier complexes barriers, particular BBB, contentious, discussed emphasis on different attempts have evinced not blood-to-endothelium, but also endothelium-to-brain.