Phyto-pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for COVID-19, based on its promising immunomodulatory, anti-coagulant and anti-viral property.

摘要: Coronavirus disease 2019 (COVID-19) triggered by a new viral pathogen, named severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), is now global health emergency. This debilitating pandemic not only paralyzed the normal daily life of community but also spread rapidly via travel. To date there are no effective vaccines or specific treatments against this highly contagious virus; therefore, an urgent need to advocate novel prophylactic therapeutic interventions for COVID-19. brief opinion critically discusses potential Silymarin, flavonolignan with diverse pharmacological activity having antiinflammatory, antioxidant, antiplatelet, and antiviral properties, versatile immune-cytokine regulatory functions, that able bind transmembrane protease serine 2 (TMPRSS2) induce endogenous cytokine interferon-stimulated gene 15, management Silymarin inhibits expression host cell surface receptor TMPRSS2 docking binding energy corresponding -1,350.61 kcal/mol full fitness score -8.11. The affinity silymarin impressive virtual exhibits significant interfere SARS-CoV-2 replication. We propose in-depth pre-clinical clinical review studies development anti-COVID-19 lead, based on its manifestations COVID-19 multifaceted bioactivities.