Local delivery of doxorubicin for malignant glioma by a biodegradable PLGA polymer sheet.

摘要: Implantable, biocompatible and biodegradable devices bearing an anticancer drug can provide promising local therapy to patients with malignant disorders. With the aim of treating brain tumors, especially gliomas, a membranous sheet containing doxorubicin was produced by co-polymerization poly(D,L-lactide-co-glycolide) (PLGA). When release from measured, sustained continued until day 34. The data contrasted burst material higher proportion drug. In terms biodegradability, subcutaneous 3 x 3-mm tetragonal almost completely absorbed 80. glioma implanted subcuteneously tumor nodule exposed sheet, device inhibited growth significantly. consisted amorphous structure cavities estimated have diameter 0.5 - Im electron microscopic observation. Since is implantable, has sustained-drug property, may play role in tumors. Malignant tumor, such as infiltrating glioblastoma, one most intractable diseases human body. invasive character rapid proliferation cells often brings recurrence disease even after radical treatment increase intracranial hypertension eventually causes herniation due limited space. median survival time 0.4 years for