The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases

摘要: Modulatory neurotransmitters which signal through G protein-coupled receptors control brain functions deteriorate in degenerative diseases. During the past decade many of these systems have been mapped zebrafish brain. The main architecture resembles that mammals, despite differences development telencephalon and mesodiencephalon. degenerate human diseases include dopamine, noradrenaline, serotonin, histamine, acetylcholine orexin/hypocretin. Although number is clearly larger than similar expression patterns, binding signaling properties as mammals. Distinct between mammals duplication tyrosine hydroxylase gene zebrafish, presence one instead two monoamine oxidase genes. Zebrafish are sensitive to neurotoxins including MPTP, exposure this neurotoxin induces a decline dopamine content detectable immunoreactive neurons distinct nuclei. Sensitivity important neurotoxins, available genetic methods, rapid large-scale quantitative behavioral methods addition advanced anatomical render an optimal organism for studies on disease mechanisms.