The Interactions of Cells with Extracellular Matrix Components

摘要: The interactions of extracellular materials with the cell surface are important facets regulation morphology and metabolism. Although it is not simple to unravel complex actions interrelationships these molecules comprising microenvironment cells, their importance now documented by a rapidly expanding literature (for recent reviews, see Hay, 1981; Chen, Kleinman et al., Aplin Hughes, 1982; Grinnell, 1983; Yamada, 1983a,b). Many major that constitute matrices have been purified. Some isolated can dramatic regulatory effects on polarity, organization cytoskeleton, production differentiated products. For example, addition purified cellular fibronectin cells deficient in restore more normal shape, adhesiveness, architecture, intracellular actin microfilaments (Yamada al.,1976a,b; Willingham 1977; Ali 1977). If certain embryonic epithelial stripped basal lamina, they cease morphogenesis begin blebbing (Banerjee al.,1977; Sugrue 1981); treatment fibronectin, laminin, or collagen sometimes (Sugrue 1981, 1982). Mammary removed from environment regain ability proliferate synthesize set products lamina if cultured within an artificial gel (e.g., Suard 1983, references therein). These many other examples macromolecules differentiation, motility, growth demonstrate milieu.