Polymers for colon specific drug delivery.
作者： Etienne Schacht , An Gevaert , El Refaie Kenawy , Koen Molly , Willy Verstraete
DOI: 10.1016/0168-3659(95)00184-0
关键词:
摘要: Azo-linked polymeric prodrugs of 5-aminosalicylic acid (5-ASA) were prepared and evaluated in simulated human intestinal microbial ecosystem. Release 5-ASA was demonstrated. Polyamides containing azo groups the backbone tested vitro a reductive buffer or bioreactor medium. It demonstrated that for hydrophobic polymer reduction stops at hydrazine stage whereas hydrophilic analogue with formation amines occurred.
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