5-Hydroxytryptamine receptor "families".
作者： Anne W. Schmidt , Stephen J. Peroutka
DOI: 10.1096/FASEBJ.3.11.2673898
关键词:
摘要: The identification of multiple receptor subtypes for 5-hydroxytryptamine (5-HT) made by using radioligand binding techniques proliferated at a brisk rate in the 1980s. application molecular biological to 5-HT studies is likely lead an expansion rather than reduction number distinct subtypes. Although current status pharmacology may appear be overwhelmingly confusing most investigators, evolving data suggest that can categorized into three major families. Each family consists share similarities their biological, pharmacological, biochemical, and/or physiological properties. This review provides summary recent as well framework classification
fasebj.org 参考文章(37)
Paul R. Hartig, Molecular Biology of the Serotonin Receptor Family Serotonin. pp. 7- 11 ,(1990) , 10.1007/978-94-009-1912-9_2
H Lubbert, TP Snutch, N Dascal, HA Lester, N Davidson, Rat brain 5-HT1C receptors are encoded by a 5-6 kbase mRNA size class and are functionally expressed in injected Xenopus oocytes The Journal of Neuroscience. ,vol. 7, pp. 1159- 1165 ,(1987) , 10.1523/JNEUROSCI.07-04-01159.1987
KA Yagaloff, PR Hartig, 125I-lysergic Acid Diethylamide Binds to a Novel Serotonergic Site on Rat Choroid Plexus Epithelial Cells The Journal of Neuroscience. ,vol. 5, pp. 3178- 3183 ,(1985) , 10.1523/JNEUROSCI.05-12-03178.1985
RE Heuring, SJ Peroutka, Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes The Journal of Neuroscience. ,vol. 7, pp. 894- 903 ,(1987) , 10.1523/JNEUROSCI.07-03-00894.1987
D. B. Pritchett, A. W. Bach, M. Wozny, O. Taleb, R. Dal Toso, J. C. Shih, P. H. Seeburg, Structure and functional expression of cloned rat serotonin 5HT-2 receptor. The EMBO Journal. ,vol. 7, pp. 4135- 4140 ,(1988) , 10.1002/J.1460-2075.1988.TB03308.X
Daniel Hoyer, Günter Engel, Hans O. Kalkman, Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin European Journal of Pharmacology. ,vol. 118, pp. 13- 23 ,(1985) , 10.1016/0014-2999(85)90658-2
H. Gozlan, S. El Mestikawy, L. Pichat, J. Glowinski, M. Hamon, Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT. Nature. ,vol. 305, pp. 140- 142 ,(1983) , 10.1038/305140A0
Jo�l Bockaert, Aline Dumuis, Rochdi Bouhelal, Mich�le Sebben, RobertN. Cory, Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 335, pp. 588- 592 ,(1987) , 10.1007/BF00169129
B. P. Richardson, G. Engel, P. Donatsch, P. A. Stadler, Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs Nature. ,vol. 316, pp. 126- 131 ,(1985) , 10.1038/316126A0
G. M. Mawe, T. A. Branchek, M. D. Gershon, Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 9799- 9803 ,(1986) , 10.1073/PNAS.83.24.9799