Systemic Capillary Leak Syndrome, Leukotrienes, and Anaphylaxis:
作者： Craig M. Lilly , Eric S. Silverman , Albert L. Sheffer
DOI: 10.1177/0885066602017004006
关键词:
摘要: The association of cysteinyl leukotrienes with plasma exudation allowed the authors to form hypothesis that rates leukotriene excretion would be increased in acute phase systemic capillary leak syndrome (SCLS) and leukotriene-modifier therapy reduce frequency severity life-threatening episodes. report SCLS 3 cases, 1 seafood-induced anaphylaxis. Rates urinary were greater during evolution an episode than after resolution. In a third case, rate was significantly higher when symptoms evolving they absent (230 ± 17 vs 110 6 pg/mg, P < 0.001). Treatment receptor (cys-LT1) antagonist eliminated episodes patient. 5-lipoxygenase inhibitor zileuton completely effective another patient prevented seafood exposure. authors' finding all...
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