Cholecalciterol cholesterol emulsion attenuates experimental autoimmune myocarditis in mice via inhibition of the pyroptosis signaling pathway.
作者： Ning Liu , Han Su , Yalin Zhang , Zuwang Liu , Juan Kong
DOI: 10.1016/J.BBRC.2017.09.006
关键词:
摘要: 1,25-dihydroxyvitamin D3 and its analog (paricalcitol) have beneficial effects on multiple systems diseases, including myocarditis. However, the therapeutic effect of cholecalciterol cholesterol emulsion (CCE) myocarditis role pyroptosis in progress not been determined. The objective this study was to investigate CCE experimental autoimmune underlying mechanisms. ratio heart weight body decreased after treatment compared with vehicle-treated controls. In addition, improved general status mice, suppressed myocardial apoptosis, inhibited signaling pathway. Therefore, can ameliorate by downregulating
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