Methods and compositions relating to fortilin, an anti-apoptotic molecule, and modulators of fortilin

摘要: The polypeptide Fortilin (also known as Translationally Controlled Tumour Protein, TCTP) specifically interacts with p53, a tumor suppressor involved in the induction of apoptosis and normal growth regulation cell. also binds MCL1 (Myeloid Cell Leukemia 1). has ability to prevent apoptosis, which may be unregulated hyperproliferative cells. present invention is directed at compositions methods involving modulator, can induce for prevention, treatment, or diagnosis diseases conditions, including cancer atherosclerosis. It Fortilin, inhibit treatment condition characterized by certain vascular conditions.