Advances in the Proteomic Discovery of Novel Therapeutic Targets in Cancer

摘要: Proteomic approaches are continuing to make headways in cancer research by helping elucidate complex signaling networks that underlie tumorigenesis and disease progression. This review describes recent advances made the proteomic discovery of drug targets for therapeutic development. A variety technical methodological overviewed with a critical assessment challenges potentials. number potential targets, such as baculoviral inhibitor apoptosis protein repeat-containing 6, macrophage inhibitory cytokine 1, phosphoglycerate mutase prohibitin fascin, pyruvate kinase isozyme 2 were identified analysis drug-resistant cells, action, differential state tissues. Future directions proteomics-based target identification validation be more translation efficient also discussed.