Fc fusion proteins of human erythropoietin with high biological activities

摘要: Fc fusion proteins of human EPO with high biological activities relative to rHuEPO on a molar basis are disclosed. The HuEPO-L-vFc protein comprises HuEPO, flexible peptide linker about 20 or fewer amino acids, and IgG variant. variant is non-lytic nature shows minimal undesirable Fc-mediated side effects. A method also disclosed make produce such at expression levels. Such exhibit extended serum half-life increased activities, leading improved pharmacokinetics pharmacodynamics, thus injections will be needed within period time.