Application of Axiomatic Design Theory to a Microfluidic Device for the Production of Uniform Water-in-Oil Microspheres Adapting an Integration Method

摘要: This work describes a novel microfluidic method to generate uniform water-in-oil (W/O) microspheres using the phase separation technique. Axiomatic design theory (ADT) was employed for conceptual of microchannel systems, and ADT verified that proposed system is decoupled design. The integration hydrodynamic flow focusing crossflow realized in device with oil aqueous phase. immiscible fluids are fed by continuous air pressure. By method, width dispersed focused controlled. enters T-junction geometry downstream, interferes flow. varying applied pressure crossflow, W/O formed at T-junction. Based on this approach, size can be successfully controlled from 16 μm 35 diameter within about 5% variation. present has advantages such as good sphericity, few satellite droplets, active control microsphere diameter, high throughput simple low cost process. To achieve promising results, integrating reveals potential production polymer based microspheres.