DNA/RNA transverse current sequencing: intrinsic structural noise from neighboring bases

摘要: Nanopore DNA sequencing via transverse current has emerged as a promising candidate for third-generation technology. It produces long read lengths which could alleviate problems with assembly errors inherent in technologies. However, the high error rates of nanopore have to be addressed. A very important source is intrinsic noise arising from carrier dispersion along chain molecule, i.e., influence neighboring bases. In this work we perform calculations within an effective multi-orbital tight-binding model derived first-principles DNA/RNA molecules, study effect structural on nanopores. We demonstrate that statistical technique, utilizing not only currents through nucleotides but also correlations currents, can principle reduce rate below any desired precision.