Positron emission tomographic studies of local cerebral glucose metabolism in humans in physiological and pathophysiological conditions.

摘要: Publisher Summary This chapter discusses the positron emission tomographic studies of local cerebral glucose metabolism in humans physiological and pathophysiological conditions. Glucose utilization is stoichiometrically related to oxygen consumption aerobic state, except a few situations such as starvation insulin hypoglycemia, provides measure energy anaerobic state well. The ability detect alterations man has become valuable tool advancing our understanding disorders affecting brain, many which are focal nature. In order determine regional metabolic rate for glucose, one must measure, distribution 18 F activity time course arterial plasma ‘ F’fluorodeoxyglucose (‘ F’FDG) concentrations, know values constants lumped constant FDG humans. three-dimensional brain determined with scanner. Such an instrument consists array scintillation detectors positioned around subject's head. mounted on gantry capable rectilinear and/or rotatory motion. From measured data, transverse sections through calculated using filtered, back-projection reconstruction technique.