Genetic Variants at 12p11 and 12q24 Are Associated with Breast Cancer Risk in a Chinese Population
作者： Zhenzhen Qin , Yanru Wang , Songyu Cao , Yisha He , Hongxia Ma
DOI: 10.1371/JOURNAL.PONE.0066519
关键词:
摘要: BACKGROUND A recent genome-wide association study (GWAS) has identified three new breast cancer susceptibility loci at 12p11, 12q24 and 21q21 in populations of European descent. However, because the genetic heterogeneity, it is largely unknown for role these non-European METHODOLOGY/PRINCIPAL FINDINGS Here, we genotyped variants (rs10771399 rs1292011 rs2823093 21q21) an independent case-control with a total 1792 cases 1867 cancer-free controls Chinese population. We found that rs10771399 were significantly associated risk per-allele odds ratios (ORs) 0.85 (95% confidence interval (CI): 0.76-0.96; P = 0.010) 0.84 CI: 0.76-0.95; P = 4.50×10(-3)), respectively, which was consistent those reported Similar effects observed between ER/PR positive negative both loci. did not significant (OR = 0.97, 95%CI = 0.76-1.24; P = 0.795). CONCLUSIONS/SIGNIFICANCE Our results indicate 12p11 may also play important development women.
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