Compositions comprising angiogenic factors and methods of use thereof
作者： Yvonne Paterson , Matthew Seavey , Paulo Maciag , Duane Sewell
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摘要: The present invention provides recombinant Listeria strains comprising an angiogenic factor, polypeptides factor operatively linked to a polypeptide PEST-like sequence, nucleotide molecules encoding same, related vaccines, and immunogenic therapeutic methods utilizing same.
lens.org 参考文章(395)
D. G. Brockstedt, M. A. Giedlin, M. L. Leong, K. S. Bahjat, Y. Gao, W. Luckett, W. Liu, D. N. Cook, D. A. Portnoy, T. W. Dubensky, Listeria-based cancer vaccines that segregate immunogenicity from toxicity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 13832- 13837 ,(2004) , 10.1073/PNAS.0406035101
Pamela Schnupf, Daniel A. Portnoy, Amy L. Decatur, Phosphorylation, ubiquitination and degradation of listeriolysin O in mammalian cells: role of the PEST‐like sequence Cellular Microbiology. ,vol. 8, pp. 353- 364 ,(2006) , 10.1111/J.1462-5822.2005.00631.X
Michael Z. Gilman, Jeffrey S. Glehn, Victoria L. Singer, Michael J. Chamberlin, Isolation of sigma-28-specific promoters from Bacillus subtilis DNA. Gene. ,vol. 32, pp. 11- 20 ,(1984) , 10.1016/0378-1119(84)90027-1
Stefan H.E. Kaufmann, Jürgen Hess, Impact of intracellular location of and antigen display by intracellular bacteria: implications for vaccine development Immunology Letters. ,vol. 65, pp. 81- 84 ,(1999) , 10.1016/S0165-2478(98)00128-X
Ayub Darji, Trinad Chakraborty, Jürgen Wehland, Siegfried Weiss, Listeriolysin generates a route for the presentation of exogenous antigens by major histocompatibility complex class I. European Journal of Immunology. ,vol. 25, pp. 2967- 2971 ,(1995) , 10.1002/EJI.1830251038
Paulo Cesar Maciag, Matthew M. Seavey, Zhen-Kun Pan, Soldano Ferrone, Yvonne Paterson, Cancer immunotherapy targeting the high molecular weight melanoma-associated antigen protein results in a broad antitumor response and reduction of pericytes in the tumor vasculature. Cancer Research. ,vol. 68, pp. 8066- 8075 ,(2008) , 10.1158/0008-5472.CAN-08-0287
Jack Kyte, Russell F. Doolittle, A simple method for displaying the hydropathic character of a protein Journal of Molecular Biology. ,vol. 157, pp. 105- 132 ,(1982) , 10.1016/0022-2836(82)90515-0
Raul M Goldschmidt, John F Barrett, Meeting Highlights: The 94th General Meeting of the American Society for Microbiology 23-27 May 1994, Las Vegas, USA Expert Opinion on Investigational Drugs. ,vol. 3, pp. 763- 765 ,(1994) , 10.1517/13543784.3.7.763
James A. Wells, Mark Vasser, David B. Powers, Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites Gene. ,vol. 34, pp. 315- 323 ,(1985) , 10.1016/0378-1119(85)90140-4
K. Ogasawara, H. Naruse, Y. Itoh, T. Gotohda, J. Arikawa, H. Kida, R. A. Good, K. Onoe, A strategy for making synthetic peptide vaccines. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 8995- 8999 ,(1992) , 10.1073/PNAS.89.19.8995