N-acetilcisteína e deferoxamina protegem contra insuficiência renal aguda induzida por isquemia/reperfusão em ratos
作者： Roberto Meister Bernardi , Larissa Constantino , Roberta Albino Machado , Francieli Vuolo , Patricia Budni
DOI: 10.1590/S0103-507X2012000300003
关键词:
摘要: OBJECTIVE: Antioxidants are widely used in animal models to prevent renal injury after ischemia/reperfusion, but it is unknown if the benefits of antioxidants additive. In this study, we aimed investigate protective effects N-acetylcysteine plus deferoxamine an model kidney ischemia/reperfusion injury. METHODS: Bilateral ischemia was mastintained for 45 minutes. N-acetylcysteine, or both were administered into aorta above arteries immediately prior induction ischemia. Five rats from each group sacrificed 1, 6 12 hours reperfusion determination blood creatinine, oxidative damage parameters and myeloperoxidase activity. RESULTS: The combination deferoxamine, not their isolated use, prevented increase creatinine ischemia/reperfusion. This prevention followed by a consistent decrease activity cortex medulla. CONCLUSION: Treatment with superior use either compound
rbti.org.br参考文章(38)
Cristiane Ritter, Michael E Andrades, Adalisa Reinke, Sérgio Menna-Barreto, José Cláudio F Moreira, Felipe Dal-Pizzol, None, Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Critical Care Medicine. ,vol. 32, pp. 342- 349 ,(2004) , 10.1097/01.CCM.0000109454.13145.CA
Bart de Vries, Sarah J. Walter, Leni von Bonsdorff, Tim G. A. M. Wolfs, L. W. Ernest van Heurn, Jaakko Parkkinen, Wim A. Buurman, Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury Transplantation. ,vol. 77, pp. 669- 675 ,(2004) , 10.1097/01.TP.0000115002.28575.E7
Hakan Erbas, Nurettin Aydogdu, Kadir Kaymak, Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury. Pharmacological Research. ,vol. 50, pp. 523- 527 ,(2004) , 10.1016/J.PHRS.2004.04.005
Radhakrishna Baliga, Zhiwei Zhang, Mithra Baliga, Norishi Ueda, Sudhir V Shah, None, In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity Kidney International. ,vol. 53, pp. 394- 401 ,(1998) , 10.1046/J.1523-1755.1998.00767.X
Murat Kizilgun, Yavuz Poyrazoglu, Yesim Oztas, Halil Yaman, Erdinc Cakir, Tuncer Cayci, Ozgur Emin Akgul, Yasemin Gulcan Kurt, Hakan Yaren, Zeki Ilker Kunak, Enis Macit, Esin Ozkan, Mine Yavuz Taslipinar, Turker Turker, Ayhan Ozcan, Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury. Renal Failure. ,vol. 33, pp. 512- 517 ,(2011) , 10.3109/0886022X.2011.574767
R A Zager, C A Foerder, Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity. Journal of Clinical Investigation. ,vol. 89, pp. 989- 995 ,(1992) , 10.1172/JCI115682
Mark S. Paller, Bo E. Hedlund, Extracellular iron chelators protect kidney cells from hypoxia/reoxygenation. Free Radical Biology and Medicine. ,vol. 17, pp. 597- 603 ,(1994) , 10.1016/0891-5849(94)90099-X
Lucas Liaudet, Jon G Mabley, Francisco Garcia Soriano, Pal Pacher, Anita Marton, GYÖRGY HASKÓ, Csaba Szabo, None, Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture American Journal of Respiratory and Critical Care Medicine. ,vol. 164, pp. 1213- 1220 ,(2001) , 10.1164/AJRCCM.164.7.2101013
Zhao-Long Wu, Mark S. Palter, Iron Loading Enhances Susceptibility to Renal Ischemia in Rats Renal Failure. ,vol. 16, pp. 471- 480 ,(1994) , 10.3109/08860229409045078
M. S. Paller, H. S. Jacob, Cytochrome P-450 mediates tissue-damaging hydroxyl radical formation during reoxygenation of the kidney. Proceedings of the National Academy of Sciences. ,vol. 91, pp. 7002- 7006 ,(1994) , 10.1073/PNAS.91.15.7002