Drug transport and targeting. Intestinal transport.

摘要: A wide variety of transporters are found in the intestine, and involved membrane transport daily nutrients as well drugs. These intestinal located brush border basolateral membrane. Each transporter exhibits its own substrate specificity, some have broader specificities than others. In addition, distribution characteristics exhibit regional differences along implying diverse physiologic functions cases pathologic responses. Indeed several genetic disorders been shown to result from deficient transporters. The development prodrugs that target has successful improving oral absorption. For example, peptide is utilized order increase bioavailability classes peptidomimetic drugs, especially ACE inhibitors β-lactam antibiotics. poorly absorbed drugs can be improved by utilization responsible for absorption various solutes and/or inhibiting efflux system. Recent advances gene cloning molecular biology techniques make it possible study at level. Based on characterizations accumulated biochemical data their kinetics, structural modification targeting a specific promising strategy design improve tissue distribution.