Goal-Directed Intraoperative Therapy Reduces Morbidity and Length of Hospital Stay in High-Risk Surgical Patients

摘要: Background Postoperative organ failures commonly occur after major abdominal surgery, increasing the utilization of resources and costs care. Tissue hypoxia is a key trigger dysfunction. A therapeutic strategy designed to detect reverse tissue hypoxia, as diagnosed by an increase oxygen extraction (O2ER) over predefined threshold, could decrease incidence failures. The primary aim this study was compare number patients with postoperative failure length hospital stay between those randomized conventional vs protocolized maintain O2ER Methods prospective, randomized, controlled trial performed in nine hospitals Italy. One hundred thirty-five high-risk scheduled for surgery were two groups. All managed achieve standard goals: mean arterial pressure > 80 mm Hg urinary output 0.5 mL/kg/h. "protocol group" (group A) also keep Measurements main results In group A, fewer had at least one (n = 8, 11.8%) than B 20, 29.8%) [p Conclusions Early treatment directed