Storage pool disease: Comparative fluorescence microscopical, cytochemical and biochemical studies on amine-storing organelles of human blood platelets

摘要: Summary. The platelet content of ATP, ADP, serotonin (5-HT), dopamine, noradrenaline and adrenaline as well the net uptake radiolabelled 5-HT mepacrine were subnormal in six patients with Storage Pool Disease (SPD). Fewer amine-storing organelles found by fluorescence microscopy fluorescent probe electron a cytochemical (uranaffin) reaction specific for 5′-phosphonucleotides. Both methods showed that SPD platelets have atypical reduced capacity to store amines, 5′-phosphonucleotides mepacrine. changes most marked two who also had oculocutaneous albinism.