Post-heparin plasma lipoprotein lipase, but not hepatic lipase activity, is related to plasma adiponectin in type 2 diabetic patients and healthy subjects

摘要: The aim of this study was to determine the relationships plasma adiponectin with post-heparin lipoprotein lipase (LPL) and hepatic (HL) activities, evaluate whether contributes diabetes-associated dyslipidaemia. Plasma adiponectin, lipoproteins insulin sensitivity (hyperinsulinaemic euglycaemic clamp) were measured in 24 male type 2 diabetic patients age-matched healthy men. triglycerides (P <0.01) apolipoprotein B levels higher, HDL cholesterol lower <0.05) patients. as well LPL HL activities not significantly different between subjects. Multiple regression analysis showed that activity positively related <0.05). In contrast, body mass index <0.02) waist/hip ratio <0.05, multiple r = 0.74), but adiponectin. associated 0.001), age 0.64), presence diabetes activity. negatively 0.002) state 0.001, 0.58). 0.003) 0.05, 0.59). We conclude activity, is appears be a determinant via an effect on It seems unlikely predicts effects such high low cholesterol.