NERVE GROWTH FACTOR : ITS SIGNIFICANCE IN CUTANEOUS BIOLOGY

摘要: Work in the past 10 y has greatly expanded our knowledge regarding role of neurotrophins and, particular, nerve growth factor, skin. During fetal development, are expressed both mesenchyme and epithelium developing skin, they play a trophic supporting survival innervating neurons. Nerve factor appears to have an important also adult organism. It serves as regulatory molecule during skin inflammation repair, affecting neuronal immune systems. Recent studies suggest that is autrocrine for keratinocytes, cells express high- lowaffinity receptors factor. Neura crest-derived melanocytes for: major injury, e.g., preventing melanocyte apoptotic cell death following UV irradiation. Thus, epidermal events interact maintain number function keratinocytes These recent insights into mechanisms underlying effects may eventually result development novel therapeutic modalities. Journal Investigative Dermatology Symposium Proceedings 2:31–36, 1997