Systems biology of IL-6, IL-12 family cytokines.

摘要: Interleukin-6-type cytokines play important roles in the communication between cells of multicellular organisms. They are involved regulation complex cellular processes such as proliferation and differentiation act key player during inflammation immune response. A major challenge is to understand how these non-linear connected regulated. Systems biology approaches used tackle this an iterative process quantitative experimental mathematical analyses. Here we review studies systems dealing with function physiological pathophysiological conditions. These cover analyses signal transduction on a level up pharmacokinetic pharmacodynamic whole organism level.