Hematopoietic Stem Cells

摘要: Hematopoietic stem cells (HSCs) represent one of the first amenable experimental models that enhanced our understanding cell behavior. Features hematopoietic system facilitating early development this model include fact is a naturally regenerative organ comprising are migratory in nature. The few or even single could be demonstrated to regenerate entire an irradiated recipient made it possible perform retrospective identification engrafting and fate its progeny. In addition, clinical interests such as gene therapy medicine have driven research understand pathways maintain modify behavior vitro vivo. This chapter reviews selection surface receptors, intracellular signaling molecules, regulators death proliferation, transcriptional known play important role maintaining HSCs adult. A large number mouse knockout studies been performed provide framework essential for maintenance steady-state hematopoiesis conditions which must regenerate. To how manipulating these affects function, phenotypic functional characterization murine human has refined over time different strains conditions, including specific animals. turn, analysis loss- gain-of-function enriched stability HSC identity.