Antibody-dependent Killing of Erythrocyte and Tumor Targets by Macrophage-Related Cell Lines: Enhancement by PPD and LPS

摘要: Five murine macrophage or monocyte-related tumor cell lines in culture were compared for antibody-dependent lysis (ADL) of a target (T lymphoma EL4) and phagocytosis sheep erythrocytes (RBC). Some effective only with RBC targets, while others capable lysing these targets. Both alloantisera to H-2 Thy 1.2 antigens on the cells rabbit anti-mouse spleen thymus sera directed lysis, normal mouse inactive. Preincubation line RAW264 lipopolysaccharide (LPS) purified protein derivative from Mycobacteria (PPD) 2 days resulted an average 76% 86% increase, respectively, ADL RBC, although there was no stimulation nonspecific These results indicate that types are macrophages probably heterogeneous effector activities, they can be stimulated increased complete absence other types.