Implementation of quantitative and systems pharmacology in large pharma.
作者： S A G Visser , D P de Alwis , T Kerbusch , J A Stone , S R B Allerheiligen
DOI: 10.1038/PSP.2014.40
关键词:
摘要: Quantitative and systems pharmacology concepts tools are the foundation of model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, enhancing submissions. Rigorous prioritization modeling simulation activities has enabled key decisions led to a high return on investment through significant cost avoidance. Critical factors successful implementation, examples impact decision making with associated investment, drivers continued success discussed.
nature.com
sci-hub.se 参考文章(45)
Kaori Ito, Brian Corrigan, Klaus Romero, Richard Anziano, Jon Neville, Diane Stephenson, Richard Lalonde, Understanding placebo responses in Alzheimer's disease clinical trials from the literature meta-data and CAMD database. Journal of Alzheimer's Disease. ,vol. 37, pp. 173- 183 ,(2013) , 10.3233/JAD-130575
Robert K. Amanfu, Jeffrey J. Saucerman, Cardiac models in drug discovery and development: a review. Critical Reviews in Biomedical Engineering. ,vol. 39, pp. 379- 395 ,(2011) , 10.1615/CRITREVBIOMEDENG.V39.I5.30
John Arrowsmith, Philip Miller, Trial Watch: Phase II and Phase III attrition rates 2011–2012 Nature Reviews Drug Discovery. ,vol. 12, pp. 569- 569 ,(2013) , 10.1038/NRD4090
Lourdes Cucurull-Sanchez, Karen G. Spink, Sterghios Athanasios Moschos, Relevance of systems pharmacology in drug discovery. Drug Discovery Today. ,vol. 17, pp. 665- 670 ,(2012) , 10.1016/J.DRUDIS.2012.01.015
R L Lalonde, K G Kowalski, M M Hutmacher, W Ewy, D J Nichols, P A Milligan, B W Corrigan, P A Lockwood, S A Marshall, L J Benincosa, T G Tensfeldt, K Parivar, M Amantea, P Glue, H Koide, R Miller, Model-based drug development. Clinical Pharmacology & Therapeutics. ,vol. 82, pp. 21- 32 ,(2007) , 10.1038/SJ.CLPT.6100235
David Orrell, Eric Fernandez, Damien Cronier, Lawrence M. Gelbert, David A. Fell, Dinesh De Alwis, Christophe Chassagnole, Abstract 4918: Predicting the effect of drug combination schedules on xenograft growth using the Virtual Tumor Cancer Research. ,vol. 71, pp. 4918- 4918 ,(2011) , 10.1158/1538-7445.AM2011-4918
Rajesh Krishna, Hans Guenter Schaefer, Ole J. Bjerrum, Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development. European Journal of Pharmaceutical Sciences. ,vol. 31, pp. 62- 67 ,(2007) , 10.1016/J.EJPS.2007.02.003
Georg E Winter, Uwe Rix, Scott M Carlson, Karoline V Gleixner, Florian Grebien, Manuela Gridling, André C Müller, Florian P Breitwieser, Martin Bilban, Jacques Colinge, Peter Valent, Keiryn L Bennett, Forest M White, Giulio Superti-Furga, Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML Nature Chemical Biology. ,vol. 8, pp. 905- 912 ,(2012) , 10.1038/NCHEMBIO.1085
Antoine Soubret, Gabriel Helmlinger, Bérengère Dumotier, Ruben Bibas, Anna Georgieva, Modeling and Simulation of Preclinical Cardiac Safety: Towards an Integrative Framework Drug Metabolism and Pharmacokinetics. ,vol. 24, pp. 76- 90 ,(2009) , 10.2133/DMPK.24.76
Antonio Cabal, Richa Y. Jayakar, Swanand Sardesai, Eual A. Phillips, John Szumiloski, Diane J. Posavec, Parker D. Mathers, Alan T. Savitz, Boyd B. Scott, Christopher T. Winkelmann, Sherri Motzel, Lynn Cook, Richard Hargreaves, Jeffrey L. Evelhoch, Bernard J. Dardzinski, Thomas N. Hangartner, Paul J. McCracken, Le T. Duong, Donald S. Williams, High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate. Bone. ,vol. 56, pp. 497- 505 ,(2013) , 10.1016/J.BONE.2013.06.011