Aluminum Phosphide Poisoning in Animals

摘要: Several articles have showed the effect of ALP toxicity on different organs. Toxicity mechanisms are not clearly understood yet. Due to potential increased use as a fumigant and lack adequate data, previous studies were re-evaluated characterize epidemiological, toxicological, clinical/ pathological aspects poisoning its management. Related terms looked up in bibliographical databases such Tehran University Medical Science Digital Library, PubMed, Scopus, Google Scholar, British library. The suggest that phosphine targets mitochondria inhibits respiration rat liver mitochondria, insect intact nematodes. On other hand, glutathione (GSH) levels reduced various tissues ALP-poisoned rats, while remaining unchanged insects mammalian cells. Also, acetylcholine signaling is an important component toxicity. Phosphine (PH 3 ) induces oxidative stress lipid peroxidation insects, cells, animals. There no known antidote for intoxication; but, melatonin effective protects against damage brain, lung, rats suggests involvement ROS genotoxicity PH . Cholinesterase inhibition responds treatment with atropine, pralidoxime, oral sweet almond oil, especially if used immediately after poisoning. treatments been animals some which tested human-beings Such should be given controlled situations hope they may helpful treating these patients.