Protein Kinases in the Regulation of Apoptosis in B-cell Chronic Lymphocytic Leukemia
作者： Montserrat Barragán , Clara Campàs , Beatriz Bellosillo , Joan Gil
DOI: 10.1080/1042819031000110964
关键词:
摘要: The involvement of several protein kinase pathways in the regulation apoptosis and cell survival has been analyzed a wide range models. This article reviews current understanding kinases involved control B-cell chronic lymphocytic leukemia (B-CLL) cells. Protein C (PKC), phosphatidylinositol 3-kinase (PI3K) nuclear factor-kappa B (NF-κB) play important roles these leukemic These affect proteins by altering their expression or function. elucidation signal transduction network B-CLL cells could provide novel pharmacological targets for therapy B-CLL.
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