Vascularization of engineered musculoskeletal tissues

摘要: Musculoskeletal tissues possess extensive vasculature, which should be recapitulated in tissue-engineering approaches. In this chapter, we review the literature pertaining to vascularization of engineered musculoskeletal tissues, and organize them along central tenets tissue-engineering: scaffolds, cells, growth factors, bioreactors. The appropriate selection design biomaterials terms structure, stiffness, porosity influence their ability direct formation vasculature. Coculture systems addition factors have been shown improve prevascularized structures. To mimicry physiology, dynamic cultures, provided via shear or mechanical stimulation, also developed demonstrated as beneficial. Despite early success engineering vascularized more work can done current strategies by systematically targeting various tissue-engineering.