Predotar: A tool for rapidly screening proteomes for N-terminal targeting sequences

摘要: Probably more than 25% of the proteins encoded by nuclear genomes multicellular eukaryotes are targeted to membrane-bound compartments N-terminal targeting signals. The major signals those for endoplasmic reticulum, mitochondria, and in plants, plastids. most abundant these well-known well-studied, but a large proportion remain unknown, including involved regulation organellar gene expression or biochemical pathways. discovery characterization means will be long difficult. An alternative method is identify candidate via their characteristic sequences. We have developed neural network-based approach (Predotar – Prediction Organelle Targeting sequences) identifying genes encoding amongst eukaryotic genome power this annotating novel families has been illustrated pentatricopeptide repeat family.