Reliability and Reproducibility of Breath Hydrogen and Methane in Male Diabetic Subjects

摘要: We studied the variability and reliability ofbreath hydrogen methane as well alterationsin intestinal gas profile in response to lactuloseingestion 13 asymptomatic male patients with diabetes mellitus (DM). Seventeen healthy subjectsserved controls. The prevalence of producerswas 33% DM 45% among control subjects (P NS). Theprevalence nonhydrogen producers was 7.7% 5.9%, respectively. coefficient forinterday variation H 72.6 ± 9.8% and49.7 controls < 0.05). 2Similarly, for interday ofCH4 94.3 18.8 69.4 ±16.8% respectively = reproducibility ofbasal H2 CH4 diabeticsas assessed by r1 (measure reliability)was poorer diabetics when breath analysis wasperformed on different days 0.001). There no significantdifference between respectto basal or peak area under curve forH2 tolactulose. conclude that there is poor fasting levelsamong diabetes. Inaddition, not associated alterations inhydrogen- methane-producing potential.