Investigations in the field of benzimidazole derivatives

摘要: The influence of the electron-donating groups CH3O, N(CH3)2, OH, NH2, CH3 in various positions benzimidazole molecule on occurrence Chichibabin reaction this series has been studied. While all monosubstituted 1-alkylbenzimidazoles undergo amination with sodium amide greater or smaller readiness, 5,5-dimethoxy-and 5,6-methylenedioxybenzimidazoles do not take part reaction. behavior derivatives toward is discussed from point view electron density at pyridine nitrogen atom and C2 imidazole ring, which was evaluated basis molecular orbital calculations, ionization constants, chemical shifts protons attached to PMR spectra.