DNA Ploidy, Cell Cycle Kinetics, and Low Versus High Grade Atypia in Endometrial Hyperplasia

摘要: There have been few studies of DNA ploidy and cell cycle kinetics in endometrial hyperplasia. The authors studied archival cases proliferative endometrium, simple, complex atypical hyperplasia well, moderately, poorly differentiated adenocarcinoma by flow cytometry also evaluated the significance degree cytologic atypia (low versus high) relative to occurrence carcinoma. All endometria, all types well moderately carcinomas were diploid. Two-thirds adenocarcinomas aneuploid. Neither S-phase fractions or (S+G2M) could distinguish among different predict which hyperplasias associated with carcinomas. was not predictive Poorly showed significant differences ploidy, S-phase, from lower grade These results support concept that there are two fundamentally