Bacterial pneumonia stimulates macromolecule secretion and ion and water fluxes in sheep trachea.

摘要: In vivo instillation of Pasteurella haemolytica (greater than or equal to 10(7) colony-forming units/kg) into a lobar bronchus sheep produced bacterial pneumonia by 7 days postinoculation. Infection was verified bacteriologically and histologically. Macromolecule secretion ion water fluxes were subsequently measured in tracheal tissues vitro compared with values from sham-infected sheep. Macromolecules radiolabeled 35SO4 [3H]threonine, we the macromolecule-bound radiolabel onto mucosa. Unidirectional Cl-, Na+, radioactive tracers under open-circuit short-circuit conditions. Lung infection increased basal bound (by 189%) [3H]-threonine 110%). It significantly net Na+ absorption open- conditions induced Cl- (16 +/- 29 microliters X cm-2 h-1). These changes associated specific recruitment neutrophils elevated levels arachidonate metabolites (thromboxane B2 leukotriene B4) airways. Thus pneumonia-induced mucus may be result airway inflammation.