Relationship between metabolism of androstenone and skatole in intact male pigs.

作者: J Babol , E J Squires , K Lundström

DOI: 10.2527/1999.77184X

关键词:

摘要: The relationship between the metabolism of androsterone and skatole, major compounds responsible for boar taint, was investigated in F 4 Swedish Yorkshire x European Wild Pig intact males. androstenone skatole were studied liver microsomes, testicular steroid production measured testes microsomes. Including assays reduced formation 6-hydroxyskatole (pro-MII), three other metabolites (P <.05). additional not affected. Liver microsomal incubations produced two metabolites, I II. rate metabolite correlated with metabolism. related to levels fat. Testicular synthesis 16-androstene steroids combined estrogens androgens, plasma androstenone, fat, Plasma estrone sulfate fat negatively F-1 pro-MII sulfation. These results indicate that are related. However, it is likely due more a link rather than liver. Sex may affect this because their biosynthesis along possible inhibition

参考文章(27)
R. Claus, B. Hoffmann, Oestrogens, compared to other steroids of testicular origin, in blood plasma of boars. European Journal of Endocrinology. ,vol. 94, pp. 404- 411 ,(1980) , 10.1530/ACTA.0.0940404
R. Claus, D. Schopper, H.-G. Wagner, SEASONAL EFFECT ON STEROIDS IN BLOOD PLASMA AND SEMINAL PLASMA OF BOARS Journal of Steroid Biochemistry. ,vol. 19, pp. 725- 729 ,(1983) , 10.1016/0022-4731(83)90003-1
Karl J. Netter, Inhibition of oxidative drug metabolism in microsomes Pharmacology & Therapeutics. ,vol. 10, pp. 515- 535 ,(1980) , 10.1016/0163-7258(80)90029-7
M. Bonneau, M. Le Denmat, J.C. Vaudelet, J.R. Veloso Nunes, A.B. Mortensen, H.P. Mortensen, Contributions of fat androstenone and skatole to boar taint: II. Eating quality of cooked hams Livestock Production Science. ,vol. 32, pp. 81- 88 ,(1992) , 10.1016/S0301-6226(12)80013-3
L Andersson, C. Haley, H Ellegren, S. Knott, M Johansson, K Andersson, L Andersson-Eklund, I Edfors-Lilja, M Fredholm, I Hansson, al. et, Genetic Mapping of Quantitative Trait Loci for Growth and Fatness in Pigs Science. ,vol. 263, pp. 1771- 1774 ,(1994) , 10.1126/SCIENCE.8134840
Bernard H. Shapiro, Arun K. Agrawal, Nisar A. Pampori, Gender differences in drug metabolism regulated by growth hormone The International Journal of Biochemistry & Cell Biology. ,vol. 27, pp. 9- 20 ,(1995) , 10.1016/1357-2725(94)00056-5
Kerstin Lundström, Birgitta Malmfors, Gunnar Malmfors, Susanne Stern, Harald Petersson, Anna Birthe Mortensen, Svend Erik Sørensen, Skatole, androstenone and taint in boars fed two different diets Livestock Production Science. ,vol. 18, pp. 55- 67 ,(1988) , 10.1016/0301-6226(88)90067-X