MP56-14 PREDICTORS AND ONCOLOGIC OUTCOMES OF PT0 PROSTATE CANCER IN RADICAL PROSTATECTOMY SPECIMENS

摘要: INTRODUCTION AND OBJECTIVES: Both low serum testosterone levels and overweight have been reported to associated with advanced prostate cancer (PC) stage grade. Even though the biological process underlying these observations is not yet fully understood. Moreover, body composition are also known be related. The aim of this study was prospectively evaluate whether levels, or obesity, both directly stage/grade in patients clinically localized PC. METHODS: Pre-operative sex hormone (total (tT) free (fT), sexual hormone-binding globulin (SHBG), mass index (BMI), waist circumference (WC) were assessed 776 consecutive European Caucasian men treated radical prostatectomy from February 2011 October 2014. results had related patient specific clinicopathologic data. RESULTS: Patients BMI 30 kg/m (n1⁄4146) WC 110 cm (highest quartile; n1⁄4210) shown significantly pathological tumor grade (Gleason Score >7; p1⁄40.012 p pT2; p1⁄40.02). vs. 7) extraprostatic disease (>pT2) lymph node metastases. On multivariable logistic regression analysis, (relative risk 2.266; 95% CI 1.169 e 4.391; p1⁄40.015) 2.539; 1.618 5.511; metastases 2.536; 1.338 4.805; p1⁄40.004) after accounting for tT age. CONCLUSIONS: This first showing that obesity but high metastatic diagnosed Our findings suggest androgen at diagnosis, which used held responsible development aggressive PC, only an epiphenomenon rather than cause PC and/or progression.