Proteins binding to the liver-specific pyruvate kinase gene promoter. A unique combination of known factors.
作者： S. Vaulont , N. Puzenat , F. Levrat , M. Cognet , A. Kahn
DOI: 10.1016/0022-2836(89)90273-8
关键词:
摘要: Abstract A 183 base-pair fragment of the liver-specific promoter L-type puruvate kinase (L-PK) gene has been shown by transfection assay to be sufficient confer a tissue-specific expression reporter gene. The proteins binding in vitro this have investigated combination DNase I footprinting, gel retardation synthetic oligonucleotides and ultraviolet cross-linking. Four from liver nuclear extracts bind fragment. They were called, 3′ 5′, L1 L4 factors. site (nucleotides −95 −66 with respect cap site) binds hepatocyte factor 1 (HNF1), protein. L2 −114 −97) ubiquitous (NF1), or related factor. L3 −144 −126) A1 (LF-A1), another Finally, −168 −145) major late transcription (MLTF/USF/UEF), an Each these detected other promoters, but their is unique L-PK
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