Serine hydroxymethyltransferase: role of the active site lysine in the mechanism of the enzyme.
作者： Douglas Schirch , Sonia Delle Fratte , Sandra Iurescia , Sebastiana Angelaccio , Roberto Contestabile
DOI: 10.1007/978-1-4615-2960-6_148
关键词:
摘要: Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate requiring enzyme which catalyzes the reaction shown in Equation 1. This uses both monoglutamate and polyglutamate forms of tetrahydrofolate (H4PteGlun) 5,10-methylenetetrahydrofolate (5,10-CH2-H4PteGlun). In eucaryotic organisms there are cytosolic mitochondrial isoenzymes. The role isoenzyme to provide 5,10-CH2-H4PteGlun for biosynthesis thymidylate, purines, methionine.1
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