Mouse and other rodent models of C to U RNA editing.
作者： Valerie Blanc , Nicholas O. Davidson
DOI: 10.1007/978-1-61779-018-8_7
关键词:
摘要: Substitutional RNA editing represents an important posttranscriptional enzymatic pathway for increasing genetic plasticity by permitting production of different translation products from a single genomically encoded template. One the best-characterized examples in mammals is C to U deamination nuclear apolipoprotein B (apoB) mRNA. ApoB mRNA undergoes single, site-specific cytidine event yielding edited transcript that results tissue-specific two distinct isoforms, referred as apoB100 and apoB48. Tissue- apoB mediated incompletely characterized holoenzyme containing minimal core complex consisting RNA-specific deaminase, Apobec-1 requisite cofactor, apobec-1 complementation factor (ACF). The underlying biochemical mechanisms regulating have been accelerated through development characterization physiological rodent models well knockout transgenic animal strains.
springer.com
sci-hub.st 参考文章(41)
R.A.K. Srivastava, Increased apoB100 mRNA in inbred strains of mice by estrogen is caused by decreased RNA editing protein mRNA. Biochemical and Biophysical Research Communications. ,vol. 212, pp. 381- 387 ,(1995) , 10.1006/BBRC.1995.1981
Nicholas O. Davidson, Gregory S. Shelness, Apolipoprotein B: mRNA Editing, Lipoprotein Assembly, and Presecretory Degradation Annual Review of Nutrition. ,vol. 20, pp. 169- 193 ,(2000) , 10.1146/ANNUREV.NUTR.20.1.169
P P Lau, D J Cahill, H J Zhu, L Chan, Ethanol modulates apolipoprotein B mRNA editing in the rat. Journal of Lipid Research. ,vol. 36, pp. 2069- 2078 ,(1996) , 10.1016/S0022-2275(20)39192-6
Anuradha Mehta, Michael T. Kinter, Nicholas E. Sherman, Donna M. Driscoll, Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNA Molecular and Cellular Biology. ,vol. 20, pp. 1846- 1854 ,(2000) , 10.1128/MCB.20.5.1846-1854.2000
Frédéric Flamant, Anne-Lise Poguet, Michelina Plateroti, Olivier Chassande, Karine Gauthier, Nathalie Streichenberger, Ahmed Mansouri, Jacques Samarut, Congenital Hypothyroid Pax8−/− Mutant Mice Can Be Rescued by Inactivating the TRα Gene Molecular Endocrinology. ,vol. 16, pp. 24- 32 ,(2002) , 10.1210/MEND.16.1.0766
M PLATEROTI, O CHASSANDE, A FRAICHARD, K GAUTHIER, J FREUND, J SAMARUT, M KEDINGER, Involvement of T3Rα- and β-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development Gastroenterology. ,vol. 116, pp. 1367- 1378 ,(1999) , 10.1016/S0016-5085(99)70501-9
Michael S. Phillips, Qingyun Liu, Holly A. Hammond, Valarie Dugan, Patricia J. Hey, C. Thomas Caskey, J. Fred Hess, LEPTIN RECEPTOR MISSENSE MUTATION IN THE FATTY ZUCKER RAT Nature Genetics. ,vol. 13, pp. 18- 19 ,(1996) , 10.1038/NG0596-18
T Funahashi, F Giannoni, A M DePaoli, S F Skarosi, N O Davidson, Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apolipoprotein B mRNA editing enzyme: functional role in the modulation of apoB mRNA editing. Journal of Lipid Research. ,vol. 36, pp. 414- 428 ,(1995) , 10.1016/S0022-2275(20)39876-X
Denise K. Bonen, Annalise M.L. Hausman, Nicholas O. Davidson, Fatiha Nassir, Inhibition of N-linked glycosylation results in retention of intracellular apo[a] in hepatoma cells, although nonglycosylated and immature forms of apolipoprotein[a] are competent to associate with apolipoprotein B-100 in vitro. Journal of Lipid Research. ,vol. 39, pp. 1629- 1640 ,(1998) , 10.1016/S0022-2275(20)32192-1
Hisatoshi Uchiyama, Ken'ichi Hirano, Masaki Kashiwasake-Jibu, Kazunari Taira, Detection of Undegraded Oligonucleotides in Vivo by Fluorescence Resonance Energy Transfer NUCLEASE ACTIVITIES IN LIVING SEA URCHIN EGGS Journal of Biological Chemistry. ,vol. 271, pp. 380- 384 ,(1996) , 10.1074/JBC.271.1.380