Synthesis of rodocaine
作者： Meng-Yang Chang , Hang-Yi Tai , Yeh-Long Chen
DOI: 10.1016/J.TET.2011.08.025
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摘要: Abstract A new method for synthesis of rodocaine (1) is presented. Two key steps were carried out by the N-bromosuccinimide (NBS)-mediated intermolecular addition known enamine 5 with allyltrimethyl silane in presence boron trifluoride etherate (BF3/OEt2) and intramolecular ring-closing metathesis triene 3. The Diels–Alder cycloaddition 3 different ethyl propiolates was also studied.
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